Hi,
i found a solution for my problem.
First, with the second alpha version the cursor was still offset & i was for giving up on animationpaper for now, because drawing with the offset is not fun. Then i searched a bit around the internet and played with my screen settings. Now everything works perfect. All i had to do was arranging the screens in the display settings differently. First i had the wacom to the right of my main screen, now it is at the bottom. So main screen top, wacom bottom solved this issue.
Greetings.