Hi Niels!
I just wanted to report that I also have this problem. I’m on Windows 11, with a Wacom One screen tablet. I have tried turning Windows Ink off and on, and tried playing around with the proportions options (not that that does much on a screen tablet), but nothing fixes the problem. The menu items (File, Edit, Draw, etc) highlight when I hover over them with my stylus, but nothing happens when I press them. Everything else works fine. I can press toolbar buttons, draw, and minimize, maximize and close the program with the standard Windows buttons at the top right.